KMID : 0370220070510020103
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Yakhak Hoeji 2007 Volume.51 No. 2 p.103 ~ p.107
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Synthesis of Novel 1,4-Disubstituted Nucleosides as Potential antitumor Agents
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Kim Ai-Hong
Hong Joon-Hee Ko Ok-Hyun
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Abstract
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In these study novel 1,4-disubstituted carbocyclic nucleoside analogues were synthesized as potential antiviral agents. The coupling reaction of the alcohol 8{alpha} with natural bases using Mitsunobu reaction afforded the target nucleosides 13, 14. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2 and HCMV. Cytosine derivative 13 exhibited moderate antiviral activity against HIV-1 (EC_{50}=16.4 {mu}M).
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KEYWORD
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disubstituted carbocyclic nucleoside synthesis, antiviral agents, Mitsunobu reaction
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